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白血病和淋巴瘤的精确分型对临床诊断、选择治疗方案及评价疗效等具有重要意义。目前,除传统的形态及组织化学分类外,又发展了一些新的技术,如细胞表面标志及生化标志。末端脱氧核苷酸转移酶(以下简称TdT)作为一种细胞内生化标志已受到广泛重视。 TdT 简介 DNA在进行自身复制时,双链解开为两条单链,在DNA聚合酶的催化下,以每条单链为模板,各自
Precise typing of leukemias and lymphomas is of great importance for clinical diagnosis, selection of treatment options and evaluation of curative effects. At present, in addition to the traditional morphological and histochemical classification, but also developed a number of new technologies, such as cell surface markers and biochemical markers. Terminal deoxynucleotidyl transferase (hereinafter referred to as TdT) as a marker of intracellular biochemistry has received widespread attention. Introduction to TdT When DNA is self-replicating, the double strand is unwound into two single strands. Under the DNA polymerase catalysis, with each single strand as a template, each