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60年代初,发现了半合成青霉素,已为人类的健康作出了伟大的贡献。由于不断研究和创新,推动抗生素进入了新的阶段——发展了半合成广谱β-内酰胺类;它包括半合成青霉素、半合成头孢菌素,以及β-内酰胺酶的抑制剂。目前合成的一些半合成青霉素,不仅对革兰阳性细菌具有良好的抗菌活性,而且对青霉素酶稳定、对耐青霉素G的金黄色葡萄球菌感染,亦具有较好的抗菌活性。同时对革兰阴性杆菌,也有一定的效果。
In the early 1960s, the discovery of semi-synthetic penicillin has made a great contribution to human health. As a result of continuous research and innovation, antibiotics have been pushed to a new stage - the development of semisynthetic broad-spectrum beta-lactams; which include semisynthetic penicillins, semisynthetic cephalosporins, and inhibitors of beta-lactamase. At present, some synthetic semisynthetic penicillins not only have good antibacterial activity against Gram-positive bacteria, but also are stable against penicillinase and against Staphylococcus aureus which is resistant to penicillin G. It also has good antibacterial activity. Gram-negative bacilli at the same time, but also have some effect.