论文部分内容阅读
阿斯匹林自1899年应用于临床,已有80余年历史。对其作用原理,研究资料甚多。目前多认为其解热、镇痛、抗炎作用可能是抑制前列腺索的生物合成所致。阿斯匹林对机体免疫力的影响研究不多,曾有人报告水杨酸盐可能通过抑制抗体的产生,干扰抗原抗体的聚集,抑制抗原在体外引起的组织胺的释放,在免疫刺激存在时能非特异性地稳定毛细血管的通透性等机制而对机体免疫过程产生影响,但水杨酸盐的这种作用需要较高的浓度。至于阿斯匹林对巨噬细胞的影响,尚未见到报告。我们采用小鼠腹腔巨噬细胞法,对阿斯匹林进行了实验研究,现报告如下:
Aspirin has been used clinically since 1899, and it has been more than 80 years old. There are many research data on its principle of action. At present, it is believed that the antipyretic, analgesic, and anti-inflammatory effects may be due to the inhibition of prostate biosynthesis. Aspirin has little effect on the body’s immunity. It has been reported that salicylate may inhibit the production of antibodies by inhibiting the production of antibodies, interfere with the accumulation of antigens and antibodies, and inhibit the release of histamine caused by the antigen in vitro, in the presence of immune stimulation. Nonspecifically stabilizing capillary permeability and other mechanisms have an impact on the body’s immune process, but this effect of salicylate requires higher concentrations. As for the effects of aspirin on macrophages, no report has yet been reached. We used the mouse peritoneal macrophage method to conduct an experimental study of aspirin. The report is as follows: