【摘 要】
:
Cellular functions are controlled by networked gene expression.Genome analysis by DNA hybridisation and sequencing has become a highly automated process.Structural analysis provides clues to biochemic
【机 构】
:
The Helmholtz Centre for Infection Research Germany
【出 处】
:
2008中国深圳蛋白质和多肽科学大会
论文部分内容阅读
Cellular functions are controlled by networked gene expression.Genome analysis by DNA hybridisation and sequencing has become a highly automated process.Structural analysis provides clues to biochemical functions of unknown proteins,but the individuality of proteins demands highly customised procedures for their expression.Automation of these procedures requires,systems that allow the efficient handling of large numbers of clones representing many different proteins.
其他文献
Ethyl (S)-4-chloro-3-hydroxybutyrate (ECHB) is an intermediate of Atorvastatin,a chiral drug for hypercholesterolemia.Rhodococcus erythropolis strain isolated from soil possessed the ability to conver
Alterations in glycan chains of the cell surface glycoconjugates are frequently implicated to modulate many biological processes such as cell-cell interaction,cell migration,differentiation and develo
The Endo-β-l,4-xylanase gene xynA from Aspergillus sulphureus,lacking signal sequence and encoding a protein of 184 amino acids,was de novo synthesized by splicing overlap extension polymerase chain r
Streptococcus pneumoniae is the major causative organisms of meningitis,bacteremia,and pneumonia.Recently,multy-drug-resistance strains of S.pneumoniae which are resistant to penicillin,broad-spectrum
Mechanobiology is indispensable to all living creatures ranging from bacteria to human beings because every living thing continually experiences mechanical stimuli,not only exogenous but also endogeno
Apeiron Biologics is a small Biotech company engaged in the development of innovative therapeutics based on validated targets derived from biomedical break-through discoveries.We are developing an Ang
Shake flask cultivation is routinely used to rank and select cell lines prior to bioreactor evaluation.Shake flask cultivation requires repetitive arid laborious manual manipulations that includes dec
Membrane proteins present unparalleled challenges for structural biology initiatives,nascent functional genomics efforts,and drug discovery experiments.To overcome some of the current hurdles in obtai
Integral membrane proteins like G-protein coupled receptors account for more than 50 % of the current drug targets,but their structural and functional characterization is still retarded by the lack of
In spite of their potential usefulness,dipeptides are poorly applied in commercial field.One major causes of this discordance is their expensiveness due to the lack of efficient manufacturing process.