Post-modifiedNMF解卷积异质化临床样本以获得特定细胞类型的基因表达

来源 :中国化学会第14 届全国计算(机)化学学术会议暨分子模拟国际论坛 | 被引量 : 0次 | 上传用户：cytunyu

【摘要】

：

纯细胞的信息的缺乏往往限制了计量学在临床数据上的运用,为此有监督学习算法开始用于估算异质化样本中特定细胞类型的基因表达情况。其中非负矩阵分解算法(non-negative matrix factorization,NMF)是常用手段之一,前人往往关注于估算特定细胞种类的表达值,而相应细胞种类在异质化样本中的比例以及所得数据的校正仍然需要进一步探索。

【作者】

：

柳媛梁羽匡启凡谢凡凡郝颖异文志宁李梦龙

【机构】

：

四川大学化学学院,四川省成都市武侯区望江路29号,610064

【出处】

：

中国化学会第14 届全国计算(机)化学学术会议暨分子模拟国际论坛

【发表日期】

：

2017年10期

【关键词】

：

癌症非负矩阵分解去卷积基因表达预后

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Post-modifiedNMF解卷积异质化临床样本以获得特定细胞类型的基因表达

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