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  5. Salubrinal improves cardiac function in a model of coronary ligation induced heart failure via a mec

Salubrinal improves cardiac function in a model of coronary ligation induced heart failure via a mec

来源 :第11届中国介入心脏病学大会 | 被引量 : 0次 | 上传用户：kongling54321
【摘 要】
：
Background The endoplasmic reticulum (ER) stress plays a vital role in mediating ischemic heart cell death.However,the role of ER stress in salubrinal therapy for isehemie heart failure (HF) has not b
【作 者】
：
LIU Yu WANG Jie WANG Dong-mei 
【机 构】
：
Department of Cardiovascular Medicine,Bethune International Peace Hospital,Shijiazhuang 050082,China
【出 处】
：
第11届中国介入心脏病学大会
【发表日期】
：
2013年7期
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Background The endoplasmic reticulum (ER) stress plays a vital role in mediating ischemic heart cell death.However,the role of ER stress in salubrinal therapy for isehemie heart failure (HF) has not been studied, The aim of the current study is to investigate the anti-ER stress effects of salubrinal, a selective eIF2a dephosphorylation inhibitor, on heart failure rats and its possible mechanisms.
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