AGE-RAGE system upregulated Connexin43 expression in rat cardiomyocytes via PKC and Erk MAPK pathway

来源 :第11届中国介入心脏病学大会 | 被引量 : 0次 | 上传用户：lafang123456

【摘要】

：

【作者】

：

YU Lu ZHAO Yan-bo XU Sheng-jie DING Fang JIN Chong-ying FU Guo-sheng WENG Shao-xiang

【机构】

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Sir Run Run Shaw Hospital,College of Medicine,Zhejiang University

【出处】

：

第11届中国介入心脏病学大会

【发表日期】

：

2013年7期

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Background The remodeling of cardiac gap junction contributes to the arrhythmias in a diabetic heart.We previously reported that high glucose reduced Cx43 protein level in neonatal rat cardiomyocytes.But the effect and mechanisms of advanced glycation end product (AGE) on Cx43 expression still remain unclear.

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AGE-RAGE system upregulated Connexin43 expression in rat cardiomyocytes via PKC and Erk MAPK pathway

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