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  5. Soluble amyloid β-enhanced LTD in rat dentate gyrus of hippocampus is mGluR1/5-dependent and involve

Soluble amyloid β-enhanced LTD in rat dentate gyrus of hippocampus is mGluR1/5-dependent and involve

来源 :中国生理学会第24届全国会员代表大会暨生理学学术大会 | 被引量 : 0次 | 上传用户：ironfeet
【摘 要】
：
Accumulation of amyloid beta (Aβ) protein is a key pathogenic element of Alzheimers disease.It is reported that the Aβ-induced impairments in synaptic plasticity (LTP and LTD) coincides with memory de
【作 者】
：
Xiaowei Chen Bangxue Zhen Zhancheng Xue Nanwei Jiang Pengyuan An Yu Wang Lan Chang Qinwen Wang 
【机 构】
：
Ningbo Key Lab of Behavioral Neuroscience
【出 处】
：
中国生理学会第24届全国会员代表大会暨生理学学术大会
【发表日期】
：
2014年7期
【关键词】
：
Alzheimer's disease amyloid beta protein metabotropic glumate receptor long 
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　　Accumulation of amyloid beta (Aβ) protein is a key pathogenic element of Alzheimers disease.It is reported that the Aβ-induced impairments in synaptic plasticity (LTP and LTD) coincides with memory decline and dementia.Although Aβ-induced inhibition of hippocampal long-term potentiation (LTP) has been intensively investigated,the underlying mechanism of Aβ-enhanced long-term depression (LTD) is not clear.
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