【摘 要】
:
Autophagy is a natural process of self-eating that occurs within cells and can be either pro-survival or can cause cell death.As a pro-survival mechanism,autophagy obtains energy by recycling cellular
【机 构】
:
Liaoning Provincial Key Laboratory of Biotechnology and Drug Discovery,Dalian 116081;College of Life
【出 处】
:
中国生理学会第24届全国会员代表大会暨生理学学术大会
论文部分内容阅读
Autophagy is a natural process of self-eating that occurs within cells and can be either pro-survival or can cause cell death.As a pro-survival mechanism,autophagy obtains energy by recycling cellular components such as macromolecules or organelles.
其他文献
Objective: Water channel aquaporin-1(AQP1)is expressed at epithelial cell plasma membranes in renal proximal tubules and thin descending limb of Henle.Recently,AQP1 was identified to interact with β-c
药物成瘾是危害人类健康的疾病之一,可卡因成瘾是药物成瘾常见的问题,目前尚无有效的治疗手段,我们的研究发现,PKD1 在可卡因成瘾中发挥了正性调控作用。(1) PKD1 广泛分布于大鼠前脑区域,在急性给与大鼠可卡因时能够增加NAc 和纹状体神经元中PKD1 的活性,而抑制PKD1 活性能够降低可卡因引起的运动活性增加;(2)PKD1 能够直接磷酸化多巴胺D1 受体S421 位点,并且由此正性调节多巴
Reactive oxygen species (ROS) are crucial in the pathogenesis of diabetic nephropathy (DN).X-box binding protein 1(XBP1),a key mediator of endoplasmic reticulum (ER) stress,has been proved having the
The mammalian target of rapamycin (mTOR) signaling pathway is a master regulator of cell growth.Recently,inhibition of mTOR complex 1 (mTORC1) with rapamycin has also been shown in both clinical and e
Aims:Induced pluripotent stem cells (iPSs) are believed to have great therapeutic potential.Treatment for acute kidney injury is challenging.Therefore,in the present study,we aimed to demonstrate if i
Two types of adipose tissue are present in mammals,white and brown (WAT and BAT).While WAT is an energy storage depot,BAT dissipates energy via the mitochondrial uncoupling protein UCP1,defending agai
Background:Albuminuria is not only an important marker of chronic kidney disease,but also a crucial contributor to tubulointerstitial inflammation (TIF).Here we determine whether activation of the Nlr
Preadipocyte and adipocyte are two major cell types that exist in white adipose tissue (WAT).The differentiation of preadipocyte increases the number of mature adipocyte and governs fat content.Trigly
The electroneutral Na+/HCO3– cotransporter NBCn2,encoded by Slc4a10,a member of the SLC4 family,is highly expressed in the brain and plays a critical role in the production of cerebrospinal fluid and
Cadmium (Cd),a toxic environmental contaminant,contributes to neurodegeneration.Rapamycin,a macrocyclic lactone,has recently shown protective effects in Cd-induced neuronal cell death.However,the unde