Activation of the Nlrp3 inflammasome by mitochondrial reactive oxygen species: A novel mechanism of

来源 :中国生理学会第24届全国会员代表大会暨生理学学术大会 | 被引量 : 0次 | 上传用户：jacklee12345678

【摘要】

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【作者】

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Dan LIU Min XU Li-hong DING Hong LIU Lin-li LV Bi-cheng LIU

【机构】

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Institute of Nephrology,Zhongda Hospital,Southeast University School of Medicine,Nanjing,China

【出处】

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中国生理学会第24届全国会员代表大会暨生理学学术大会

【发表日期】

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2014年7期

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Background:Albuminuria is not only an important marker of chronic kidney disease,but also a crucial contributor to tubulointerstitial inflammation (TIF).Here we determine whether activation of the Nlrp3 inflammasome is involved in albuminuria induced-TIF and the underlying mechanisms of inflammasome activation by mitochondrial reactive oxygen species (mROS).

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