【摘 要】
：
The purpose of this study was to investigate the effect of Ca2+/calmodulin (CaM) on voltage-gated sodium channels (VGSCs) in cultured hippocampal neurons exposed to low Mg2+ (low Mg2+ neurons).Our dat
【机 构】
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中国医科大学药学院药物毒理学教研室,沈阳 110001
【出 处】
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中国生理学会第24届全国会员代表大会暨生理学学术大会
论文部分内容阅读
The purpose of this study was to investigate the effect of Ca2+/calmodulin (CaM) on voltage-gated sodium channels (VGSCs) in cultured hippocampal neurons exposed to low Mg2+ (low Mg2+ neurons).Our data showed that the VGSC activity,which is associated with a persistent,noninactivating Na+ current (INa,P),was modulated by CaM in a concentration-dependent manner in both normal neurons and low Mg2+ neurons,but the channel activity in low Mg2+ neurons was more sensitive to Ca2+/CaM regulation than that in normal neurons,as determined by patch–clamp.
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