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Background:Alcohol dehydrogenase-1B(ADH1B) and aldehyde dehydrogenase-2(ALDH2) genes are closely correlated with liver alcohol metabolism,as well as other liver diseases.The purpose of this study was to investigate the relationships of ADH1B and ALDH2 single nucleotide polymorphisms(SNPs) with hepatitis B virus(HBV)infection in a Chinese sample.