Formation of dendrimer-modified MoS2 nanoflowers for combinational gene silencing and photothermal t

来源 :中国微米纳米技术学会纳米科学技术分会第四届年会暨2016国际纳米生物与医学学术会议 | 被引量 : 0次 | 上传用户：gkchenvip

【摘要】

：

【作者】

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Lingdan Kong Lingxi Xing Lianfang Du Xiangyang Shi

【机构】

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State Key Laboratory for Modification of Chemical Fibers and Polymer Materials,College of Chemistry,

【出处】

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中国微米纳米技术学会纳米科学技术分会第四届年会暨2016国际纳米生物与医学学术会议

【发表日期】

：

2016年5期

【关键词】

：

MoS2 nanoflowers photothermal therapy Bcl-2 siRNA gene silencing

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　　Exploitation of novel hybrid nanomaterials for combinational tumor therapy still remains to be challenging.In this work,we develop a novel dendrimer-modified MoS2 nanoflowers for combinational gene therapy and PTT of cancer cells.MoS2 nanoflowers synthesized via a hydrothermal approach were modified with generation 5(G5)poly(amidoamine)dendrimers partially functionalized with lipoic acid via disulfide bond.The formed G5-MoS2 nanoflowers display good colloidal stability and superior photothermal conversion efficiency and photothermal stability.

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