【摘 要】
：
Photo-induced nanomedicine of organic fluorophores is of particular interest as an emerging paradigm towards precise cancer therapy.However,there has been explored with limited success in the developm
【机 构】
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College of Pharmaceutical Sciences,Soochow University,Suzhou 215123,China;School of Radiation Medici
【出 处】
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中国微米纳米技术学会纳米科学技术分会第四届年会暨2016国际纳米生物与医学学术会议
论文部分内容阅读
Photo-induced nanomedicine of organic fluorophores is of particular interest as an emerging paradigm towards precise cancer therapy.However,there has been explored with limited success in the development of available nanoparticles that can induce the ultra-low radiative transition of fluorophore for photo-induced tumor ablation.Here,we report the bifunctional self-assembled nanoparticles of platinated boron dipyrromethene core(Bodiplatin-NPs)with ultra-low radiative transition for photo-induced tumor ablation.Bodiplatin-NPs can produce both remarkable singlet oxygen and photothermal effect through their preferable singlet-to-triplet transition and non-radiative decay under single-wave light irradiation,thereby generating abundant reactive oxygen species(ROS)and simultaneous potent hyperthermia at tumors.Moreover,Bodiplatin-NPs exhibit good resistance to photo-bleaching,negligible dark toxicity,effective intracellular translocation from the lysosomes to cytoplasma,and preferable tumor accumulation,facilitating remarkable photo-induced cell damage and subsequent synergy between PDT and PTT for tumor ablation.Our proof-of-concept design of self-assembled nanostructure with platinated fluorophore core represents a general and versatile approach for photo-induced tumor ablation.
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