Metabolic engineering of Escherichia coli to enhance acetol production from glycerol

来源 :中国生物工程学会第六次全国会员代表大会暨第九届学术年会 | 被引量 : 0次 | 上传用户：wenhao

【摘要】

：

Acetol,a C3 keto alcohol,is an important intermediate used to produce polyols and acrolein.To enhance acetol production from glycerol by Escherichia coli,a muta

【作者】

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Ruilian Yao Qing Liu Hongbo Hu Thomas K.Wood Xuehong Zhang

【机构】

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StateKeyLaboratoryofMicrobialMetabolism,SchoolofLifeSciencesandBiotechnology,ShanghaiJiaoTongUnivers

【出处】

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中国生物工程学会第六次全国会员代表大会暨第九届学术年会

【发表日期】

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2015年11期

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Acetol,a C3 keto alcohol,is an important intermediate used to produce polyols and acrolein.To enhance acetol production from glycerol by Escherichia coli,a mutant (HJ02) was constructed by replacing the native glpK gene with the allele from E.coli Lin43 and overexpression of yqhD,which encodes aldehyde oxidoreductase YqhD that converts methylglyoxal to acetol.

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Metabolic engineering of Escherichia coli to enhance acetol production from glycerol

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