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Cell cycle-dependent temporal transcription of genes is achieved by different mechanisms including a dynamic interaction of activator and repressor proteins with promoters,accumulation and/or degradation of key regulators as a function of cell cycle.We find that response regulator TorR protein of TorR/TorS two component system targets the old pole of the Escherichia coli cell as a biologically active focus.Importantly,interaction of TorR focus with chromosomal DNA is dependent on cell cycle progression and by which regulates transcription of a number of genes associated with Fe2+ transport.