【摘 要】
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Introduction: Isoproterenol, a synthetic non-selective β-adrenergic agonist, is often used during the immediate postoperative period after open heart surgery for its chronotropic and vasodilatory effe
【机 构】
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Department of Molecular Immunology,Institute of Basic Medical Sciences,27 Taiping Road,Beijing 10085
【出 处】
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International Conference for Physiological Sciences 2012(201
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Introduction: Isoproterenol, a synthetic non-selective β-adrenergic agonist, is often used during the immediate postoperative period after open heart surgery for its chronotropic and vasodilatory effects.Mediastinal sepsis following open heart surgery is a significant cause of death.It remains unclear how isoproterenol infusion might affect sepsis.Methods: We investigated the effects of 24 hour-isoproterenol pretreatment on septic shock induced by experimental endotoxemia and bacterial peritonitis, with cholera toxin as another cAMP elevator.Results: Unexpectedly, we found isoproterenol and cholera toxin exhibited distinct effects in acute lethal systemic inflammatory response.Isoproterenol worsened liver injury without enhancing NK/NKT activity.Meanwhile,isoproterenol enhanced TNF-α response whereas cholera toxin showed the opposite roles.Further exploration revealed that isoproterenol, but not cholera toxin, augmented CD14 expression in neutrophils, which was associated with elevated production of TNF-α in response to LPS.Conclusion: Our data provide a caution for the clinical use of isoproterenol and suggest that isoproterenol has cAMP-independent functions.
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