【摘 要】
：
Dendritic trees influence synaptic integration and neuronal excitability, yet appear to develop in rather arbitrary patterns.Using electron microscopy and serial reconstructions, we analyzed the dendr
【机 构】
：
National Institute for Physiological Sciences,Japan;SOKENDAI,Japan;CREST-JST,Japan
【出 处】
：
International Conference for Physiological Sciences 2012(201
论文部分内容阅读
Dendritic trees influence synaptic integration and neuronal excitability, yet appear to develop in rather arbitrary patterns.Using electron microscopy and serial reconstructions, we analyzed the dendritic trees of four morphologically distinct neocortical interneuron subtypes to reveal two underlying organizational principles common to all.First, cross-sectional area at any given point within a dendrite is proportional to the summed length of all distal segments spanning beyond it.Second, the total cross-sectional area is perfectly conserved at bifurcation points.Third, dendritic cross-sections become more elliptic at proximal locations, resulting in a conservation of the surface to volume ratio throughout the dendritic tree.Finally, computer simulations revealed that these conserved morphological features limit distance dependent filtering of somatic EPSPs and facilitate distribution of somatic depolarization into all dendritic compartments.Because these features were shared by all intemeurons studied, they may represent common organizational principles underlying the otherwise diverse morphology of dendritic trees.
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