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Intracerebral hemorrhage (ICH) remains a serious clinical problem lacking effective treatment.ICH frequently causes brain edema, which leads to an expansion of brain volume and worsens ICH outcomes.Increasing evidence suggests that inflammatory cascades are involved in ICH-induced brain edema.Urocortin 1(UCN), a member of the corticotropin-releasing factor family, protects ischemic cardiomyocytes and dopaminergic neurons.In this study, we examined the therapeutic effect of UCN on ICH-induced neurological deficits and neuroinflammation.ICH was induced in male Sprague-Dawley rats by intrastriatal infusion of bacterial collagenase Ⅶ-S or autologous blood.