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A key technical challenge confronting the comprehensive analysis of complex protein mixtures is the dynamic range of protein abundances that spans over 10 orders of magnitude.High abundance proteins hinder the detection of hundreds of low abundance proteins, some of which might potentially be relevant to a particular biological process.In order to facilitate the analysis of such low abundance proteins, a rapid, inexpensive and a simple method is required to remove the high abundant proteins and/or enrich the high abundant proteins.Several approaches have been exploited for removing abundant proteins from complex protein mixtures.