【摘 要】
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目的 Targeted therapy has become a valuable approach in adenocarcinoma of the lung. The number of actionable mutations has been continuously increasing with significant acceleration from discovery to cl
【机 构】
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DepartmentofRespiratoryMedicine,RuijinHospital,ShanghaiJiaoTongUniversitySchoolofMedicine
【出 处】
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2016中华医学会呼吸病学年会暨第十七次全国呼吸病学学术会议
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目的 Targeted therapy has become a valuable approach in adenocarcinoma of the lung. The number of actionable mutations has been continuously increasing with significant acceleration from discovery to clinical application. 方法 We herein describe a case of innovative treatment using targeted therapy of a 63-year-old metastatic adenocarcinoma female with dual mutation. 结果 It was an interesting case of rapid response to crizotinib in de novo c-met-amplified adenocarcinoma detected by the method of Q-PCR in circulating blood platelets in a patient carrying initially an activating mutation in exon 19 of the epidermal growth factor receptor (EGFR) detected by the method of CAST-PCR in peripheral blood. The initial treatment was gefitinib which responded favorably for three months. Off-label use of crizotinib, a potent inhibitor of c-met, was additionally prescribed when the second blood test showed a c-met (P.R982G, 5784/17[0.003] amplification. Within 4 weeks of treatment initiation, the tumor, the dependent lymphadenopathy, the malignant pleural effusion and the cerebral metastasis responded with rapid shrinkage.
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