Structural Insights into Chitinolytic Enzymes and Inhibition Mechanisms of Selective Inhibitors

来源 :第十一届全国酶学学术讨论会暨邹承鲁诞辰90周年纪念会 | 被引量 : 0次 | 上传用户：k5261715

【摘要】

：

　　Chitin biodegradation is linked to fungi cell differentiation, nematode egg hatching, arthropods morphogenesis, and human defense against malaria and other

【作者】

：

刘田陈磊沈旭杨青

【机构】

：

大连理工大学生命科学与技术学院,大连116024中国科学院上海药物研究所,上海201203

【出处】

：

第十一届全国酶学学术讨论会暨邹承鲁诞辰90周年纪念会

【发表日期】

：

2013年5期

【关键词】

：

chitin chitinase hexosaminidases crystal structure inhibitor

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　　Chitin biodegradation is linked to fungi cell differentiation, nematode egg hatching, arthropods morphogenesis, and human defense against malaria and other pathogens infection as well.Two classes of enzymes for chitin degradation include glycosyl hydrolase (GH) family 18 chitinases and family 20 β-N-acetyl-D-hexosaminidases.

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Structural Insights into Chitinolytic Enzymes and Inhibition Mechanisms of Selective Inhibitors

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