Structural basis of the changes in enzyme activity caused by deletion mutations in the β12-β13 loops

来源 :第十一届全国酶学学术讨论会暨邹承鲁诞辰90周年纪念会 | 被引量 : 0次 | 上传用户：youshouyao

【摘要】

：

　　PP1, PP2A, and PP2B, three representative protein Ser/Thr phosphatases in PPPs, all contain typical catalytic cores with β12-β13 loops.Our previous studie

【作者】

：

Hao Zhang WenChang Zhou ZhiGuang Jia Hui Li Qun Wei

【机构】

：

DepartmentofBiochemistryandMolecularBiology,CollegeofLifeScience,BeijingNormalUniversity,BeijingKeyL

【出处】

：

第十一届全国酶学学术讨论会暨邹承鲁诞辰90周年纪念会

【发表日期】

：

2013年5期

【关键词】

：

molecular dynamic docking mutagenesis studies hydrogen bond substrate binding

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　　PP1, PP2A, and PP2B, three representative protein Ser/Thr phosphatases in PPPs, all contain typical catalytic cores with β12-β13 loops.Our previous studies showed that deletion mutations at corresponding sites of the β12-β13 loops in PP2B-A and PP1 caused very similar changes in enzyme activity.

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Structural basis of the changes in enzyme activity caused by deletion mutations in the β12-β13 loops

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