【摘 要】
：
This study we examined whether the premature osteoporosis caused by Bmil deficiency was associated with oxidative stress-induced bone aging.We treated Bmil-/-mice with the antioxidant N-acetylcysteine
【机 构】
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The Research Center for Bone and Stem Cells, Nanjing Medical University, China
【出 处】
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The 18th Congress of the International Federation of Associa
论文部分内容阅读
This study we examined whether the premature osteoporosis caused by Bmil deficiency was associated with oxidative stress-induced bone aging.We treated Bmil-/-mice with the antioxidant N-acetylcysteine, and compared their phenotype with the untreated Bmil-/-and WT mice.NAC supplementation of Bmil-/-mice resulted in a longer lifespan ,increased body weight , BMD, cortical and trabecular bone volume, osteoblast numbers, ALP and type Ⅰ collagen positive areas , MAR, total antioxidant capacity,glutathione concentration, and SOD level, whereas a reduced number of bone marrow adipocytes, the percentages of 8-hydroxy-2-deoxyguanosine positive or β-galactosidase positive osteocytes, the protein expression levels of PPARγ,γ-H2AX and p l 6INK4a, H2O2 concentration and MDA content.
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