【摘 要】
：
目的：建立HPLC法测定注射用比阿培南的含量,并考察其与0.9%氯化钠、5%葡萄糖、10%葡萄糖、葡萄糖氯化钠、复方氯化钠注射液配伍的稳定性。方法：采用色谱柱Symmetry C18(4.6×150mm,5μm)、醋酸盐缓冲液：乙腈(100：3,v/v)流动相、检测波长294nm；在25℃、室内自然光照射下观察配伍液的外观变化,同时监测配伍液pH值及比阿培南含量的变化。结果：比阿培南标准曲线线性范
【机 构】
：
福建医科大学附属第一医院药学部,福州市 350005 福建医科大学药学系,福州市 350005
【出 处】
：
福建省科协第九届学术年会卫星会议——福建省药学会2009年学术年会
论文部分内容阅读
目的：建立HPLC法测定注射用比阿培南的含量,并考察其与0.9%氯化钠、5%葡萄糖、10%葡萄糖、葡萄糖氯化钠、复方氯化钠注射液配伍的稳定性。方法：采用色谱柱Symmetry C18(4.6×150mm,5μm)、醋酸盐缓冲液：乙腈(100：3,v/v)流动相、检测波长294nm；在25℃、室内自然光照射下观察配伍液的外观变化,同时监测配伍液pH值及比阿培南含量的变化。结果：比阿培南标准曲线线性范围0.01～1.0mg·mL-1。r=0.9998(n=8)；平均回收率99.57%,RSD1.30%,最低定量限58ng·mL-1(S/N≥10)。在0.9%氯化钠注射液或复方氧化钠注射液中10h、5%葡萄糖注射液中8h、10%葡萄糖注射液中9h、葡萄糖氯化钠注射液中7h,比阿培南的含量变化均<5%；5种配伍液pH值经时均略降低,但皆未超出药典规定范围。葡萄糖氯化钠配伍液6h外观颜色开始发生改变。结论：在25℃室内自然光照射下,比阿培南可与本文5种输液配伍使用,但须注意稳定时间有所差别；与葡萄糖氯化钠注射液配伍后宜于5h内给药完毕。本文建立的HPLC法适用于比阿培南含量测定。
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