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Purpose:Association of a polymorphism rs3775291 in the toll-like receptor 3 (TLR3)gene with age-related macular degeneration (AMD) had been investigated intensively with inconsistent results from different studies.Here we conducted a meta-analysis to verify the effect ofrs3775291 on AMD.Methods:We searched for genetic association studies published in the PubMed,EMBASE and Web of Science databases from start dates to March 10,2015.Totally 235 reports were retrieved and studied.