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  5. Application of Common Mutation Screening by HRM and Subsequent Direct Full Mitochondrial DNA Sequenc

Application of Common Mutation Screening by HRM and Subsequent Direct Full Mitochondrial DNA Sequenc

来源 :第六届全国眼科学研究生学术论坛暨眼科细胞及再生生物学世界大会 | 被引量 : 0次 | 上传用户：haschie
【摘 要】
：
Purpose:The aim of this study was to establish a fast,simple,and accurate mutation-detection approach to select patients with Leber Hereditary Optic Neuropathy (LHON) and carrying a mutation at nucleo
【作 者】
：
Heng He Bin Li 
【机 构】
：
Department of Ophthalmology,Tongji Hospital,Tongji Medical College,Huazhong University of Science an
【出 处】
：
第六届全国眼科学研究生学术论坛暨眼科细胞及再生生物学世界大会
【发表日期】
：
2015年6期
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Purpose:The aim of this study was to establish a fast,simple,and accurate mutation-detection approach to select patients with Leber Hereditary Optic Neuropathy (LHON) and carrying a mutation at nucleotide position 11778 in the mitochondrial DNA (mtDNA) but no other mitochondrial mutations for AAV vector-delivered NADH-ubiquinone oxidoreductase,subunit 4 (AAV2-ND4) gene therapy.
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