An integrated approach for the discovery of functional anti-human ICAM-1 antibodies

来源 :上海浦东免疫化学国际生物论坛 | 被引量 : 0次 | 上传用户:wl7644719
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Human intercellular adhesion molecule-1 (ICAM-1) is an attractive target for development of new therapies to prevent rhinovirus infection by blocking virus-receptor binding.By an integrated approach, we are discovering and developing such antibodies with high affinity for therapeutic purposes.
其他文献
The hedgehog (Hh) signaling pathway plays a very important role in metazoan development by controlling pattern formation.Drosophila imaginal discs are subdivide
会议
Misconduct in science has always occurred, but has increased dramatically in recent times.A number of reasons have contributed to the phenomenon: the enormous e
会议
  Our previous studies indicate that phosphatidylinositol 4-kinase IIα can promote the growth of multi-malignant tumors via HER-2/PI3K and MAPK pathways.Howe
The AAA+ ATPase Vps4 is essential for HIV-1 budding, multivesicular body biogenesis, cytokinesis, and other pathways through its ability to disassemble the ESCR
会议
In many cases interactions between protein and DNA are regulated by a third species.A convenient method to analyze the interaction between protein and DNA, and
会议
Connexins (Cx) are tetraspan transmembrane proteins that form hexameric assemblies in the plasma membrane known as hemichannels or connexons.When two hemichanne
Detergent micelles are widely used membrane-mimetic models in membrane protein study.DPC has an identical head group to phosphatidylcholines in human cells, so
会议
c-met is a chemokine receptor widely expressed on the membrane of different kinds of cells in the body including hepatocytes, and it plays a significant role in
会议
Kisspeptins, a family of peptide products derived from the KiSS-1 gene, activate their cognate receptor GPR54 in various target tissues to exert disparate funct
会议
Intrinsically disordered proteins (IDPs) perform their physiological role without possessing a well-defined threedimensional structure.Still, residual structure
会议