• 不 限
  • 期刊论文
  • 硕博论文
  • 会议论文
  • 报 纸
  • 英文论文
  2. 您的位置
  3. 首页
  4. 会议论文
  5. Dual inhibition of EGFR at protein and activity level via combinatorial blocking of PI4KIIα as anti-

Dual inhibition of EGFR at protein and activity level via combinatorial blocking of PI4KIIα as anti-

来源 :上海浦东免疫化学国际生物论坛 | 被引量 : 0次 | 上传用户：langjitianya198411
【摘 要】
：
　　Our previous studies indicate that phosphatidylinositol 4-kinase IIα can promote the growth of multi-malignant tumors via HER-2/PI3K and MAPK pathways.Howe
【作 者】
：
Jiangmei Li Lunfeng Zhang Zhen Gao Hua Kang Guohua Rong Xu Zhang Chang Chen 
【机 构】
：
NationalLaboratoryofBiomacromolecules,InstituteofBiophysics,ChineseAcademyofSciences,Beijing,ChinaNa
【出 处】
：
上海浦东免疫化学国际生物论坛
【发表日期】
：
2015年11期
【关键词】
：
Phosphatidylinositol 4-kinase Iiα (PI4KIIα) EGFR Dual inhibition Enhanced anti-t 
下载到本地 , 更方便阅读
下载此文 赞助VIP
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
　　Our previous studies indicate that phosphatidylinositol 4-kinase IIα can promote the growth of multi-malignant tumors via HER-2/PI3K and MAPK pathways.However, the molecular mechanisms of this pathway and its potential for clinical application remain unknown.
其他文献
Probing Transient Conformational States of Protein
Short-lived conformational states in proteins are fundamental to protein function, but tend to be difficult to detect due to their transient nature such as intr
会议
Molecular insights into the membrane-associated phosphatidylinositol 4-kinase IIα
Phosphatidylinositol 4-kinase IIα (PI4KIIα), a membrane-associated PI kinase, plays a central role in cell signaling and trafficking.Its kinase activity criti
会议
Screening for neutralizing antibody against Ebloa virus
The current (from February 2014) Ebola virus disease (EVD) outbreak in West Africa is the largest one, and spread at an alarming rate, the mortality rate is abo
会议
Deorphan Human Olfactory Receptors
About 400 human olfactory receptors (ORs) can discriminate ＞1trillion olfactory stimuli.However,how they make the impossible to happen remains elusive.In fact, m
会议
Understanding GPCR diversity and ligand specificity from the big data in virtual screening
As the most important transmembrane signaling modulator, G protein-coupled receptors (GPCRs) are the most valuable therapeutic targets while GPCR-targeting drug
会议
Connexin 26 hemichannel as target for antibody therapy
Gap junction channels mediate communication between adjacent cells by allowing the passage of a variety of cytoplasmic molecules.They are formed by the head to
会议
Colloidal quantum dot surface engineering
Colloidal quantum dots (CQDs) are nanoparticles that can be dispersed in solution.Their quantum confinement character endows CQDs with tuneable optoelectronic p
会议
PI4KIIα is a novel regulator of tumor growth via its action on angiogenesis and HIF-1α regulation
Tumor growth is the orchestration of various oncogenes and tumor suppressors, and the regulation of these genes offers a rational therapeutic approach for cance
会议
The Kto-Skd Complex Can Regulate ptc Expression by Interacting with Cubitus interruptus (Ci) in the
The hedgehog (Hh) signaling pathway plays a very important role in metazoan development by controlling pattern formation.Drosophila imaginal discs are subdivide
会议
FRAUDS, ERRORS, SLOPPY RESEARCH THE DARK SIDE OF SCIENCE
Misconduct in science has always occurred, but has increased dramatically in recent times.A number of reasons have contributed to the phenomenon: the enormous e
会议