【摘 要】
：
Tumor growth is the orchestration of various oncogenes and tumor suppressors, and the regulation of these genes offers a rational therapeutic approach for cance
【机 构】
：
NationalLaboratoryofBiomacromoleculesNationalLaboratoryofBiomacromolecules;ChineseAcademyofSciences-
论文部分内容阅读
Tumor growth is the orchestration of various oncogenes and tumor suppressors, and the regulation of these genes offers a rational therapeutic approach for cancer treatment.Here we found a new regulator of tumor growth, phosphatidylinositol 4-kinase type IIα (PI4KIIα), and the mechanism is involved in angiogenesis and HIF-1α regulation.Results from a human cancer tissue microarray showed that PI4KIIα protein expression increases markedly in 7 types of cancers compared with normal tissues.Suppression of PI4KIIα leads to retarded tumor growth in nude mice.
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