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As more and more biomedical applications of graphene oxide(GO)and its derivatives been explored,critical issues as their biosafety and biological effects arise and must be addressed before any further massive applications.My group is currently working on the biological effects of GO and its derivatives.In our recent work,we fabricate 3 types of GO-based nanomaterials: a series of GO-Ag nanocomposites(GO-Ag)& GO-IONP-Ag nanocomposites with different AgNPs to GO ratios,and a series of PEGlyated GO(GO-PEG)with different PEG contents.