• 不 限
  • 期刊论文
  • 硕博论文
  • 会议论文
  • 报 纸
  • 英文论文
  2. 您的位置
  3. 首页
  4. 会议论文
  5. The sedative-hypnotic effect of YZG-330 and its influence on the expression of p-CaMKⅡ in mouse hypo

The sedative-hypnotic effect of YZG-330 and its influence on the expression of p-CaMKⅡ in mouse hypo

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：xixixi
【摘 要】
：
Aim: Ca/calmodulin-dependent protein kinase (CaMKII) was a critical molecule for the regulation of the wake-sleep cycle.The level of CaMKII phosphorylation (pCaMKII) was positively related with the to
【作 者】
：
Li-ne TANG Yuan SHI Jing-wen DONG Jian-jun ZHANG 
【机 构】
：
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia
【出 处】
：
The 12th Meeting of the Asia Pacific Federation of Pharmacol
【发表日期】
：
2013年4期
【关键词】
：
p-CaMKⅡ sedative-hypnotic hypothalamus 
下载到本地 , 更方便阅读
下载此文 赞助VIP
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Aim: Ca/calmodulin-dependent protein kinase (CaMKII) was a critical molecule for the regulation of the wake-sleep cycle.The level of CaMKII phosphorylation (pCaMKII) was positively related with the total percentage of time spent in wakefulness, pCaMKⅡ inhibitor could decrease wakefulness and increase SWS and REM sleep.This study was designed to explore whether YZG-330 had a sedativehypnotic effect and determine the role of pCaMKII in the regulation of sleep.
其他文献
Protocatechuic acid protects primary astrocytes against MPP+-induced oxidative stress and apoptosis
Aim: Protocatechuic acid (PCA), a phenolic compound, has been reported to exert neuroprotective effects, but its effect on astrocytes has not been studied.The aim of this paper is to investigate wheth
会议
protocatechuic acidoxidative stressapoptosismitochondrial membrane potential
A transmembrane accessory subunit that modulates kainate-type glutamate receptors
Glutamate receptors play major roles in excitatory transmission in the vertebrate brain.Among ionotropic glutamate receptors (AMPA, kainate, NMDA), AMPA receptors mediate fast synaptic transmission an
会议
Effects of HSW on mice model of Parkinson's disease induced by MPTP
Aim: To observe the effects of HSW on behavior and content of dopamine (DA), DOPAC and HVA in the striatum of mice treated with 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP).Methods: C57BL mi
会议
PDCs7BL micebehavior testdopamine
Anti-apoptotic and neuroprotective effects of oxysophoridine on cerebral ischemia both in vivo and i
Aim: In this study we investigated the neuroprotective effect of oxysophoridine (OSR) on ischemia and ischemia-like insults.Methods: Protection by oxysophoridine (OSR) was studied in vivo level using
会议
oxysophoridine (OSR)Cerebral ischemiamiddle cerebral artery occlusion (MCAO)o
B2 induces sedative and hypnotic effects via activating the hypothalamic ventrolateral preoptic neur
Aim: B2 is a novel derivative of N6-(4-hydroxybenzyl) adenine riboside originally isolated from Gastrodia elata Blume.The ventrolateral preoptic nucleus (VLPO) is a group of neurons in the hypothalamu
会议
ventrolateral preoptic areainsomniahypnoticssleepy-aminobutyric acid
Effects of MNG on neurogenesis and Wnt signaling after focal cerebral ischemia in rats
Aim: To investigate the effects of MNG extracted from Cornus officinalis on neurogenesis and Wnt signaling after focal cerebral ischemia reperfusion in rats.Methods: Focal stroke was induced in adult
会议
MNGcerebral ischemianeurogenesisWnt signaling
Antidepressant effect of Xiaochaihutang in the unpredictable chronic mild stress model via increasin
Aim: Xiaochaihutang (XCHT) has been used in China for thousands of years to treat "Shaoyang syndrome", which involves depressive-like symptoms.Previous studies in our laboratory have showed that XCHT
会议
XCHTCUMSBDNFTrkBhippocampus
Sphingosine kinase 2-mediated autophagy contributes to preconditioning by isoflurane in mouse cortic
Aim: Sphingosine kinase 2 (SPK2) and autophagy are both involved in cerebral preconditioning, but whether preconditioning-induced SPK2 upregulation and autophagy activation are linked mechanistically
会议
sphingosine kinase 2isoflurane preconditioningautophagycortical neuronscoimm
An α1-adrenoceptor antagonist: DDPH can efficiently attenuated the decreased expression of HCN1 mRNA
Aim: DDPH (1-(2,6-dimethylphenoxy)-2-(3, 4-dimethoxyphenylethylamino) propane hydrochloride), a candidate drug known to be an a1-adrenoceptor antagonist,can efficiently penetrate through blood brain b
会议
DDPHHCN1 mRNArt-PCRchronic ischemia
Transient augment of IL-1β promotes seizure susceptibility via upregulating CB1 receptor in prolonge
Aim: This study was to investigate the role of IL-1β in the enhanced seizure susceptibility after prolonged febrile seizures (FSs).Methods: Rats or mice pups (P8) were exposed to a hyperthermal chambe
会议
prolonged febrile seizuresepileptogenesisIL-1βCB1R