【摘 要】
：
Citrush ydroxylated polymethoxyflavones (PMFs), exist exclusively in citrus genus, have been reported to exhibit a broad spectrum of biological activity.Here we investigated the chemopreventive effect
【机 构】
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Department of Seafood Science National Kaohsiung Marine University Taiwan
【出 处】
：
BITs 3rd Annual World Cancer Congress-2012(2012第五届世界癌症大会)
论文部分内容阅读
Citrush ydroxylated polymethoxyflavones (PMFs), exist exclusively in citrus genus, have been reported to exhibit a broad spectrum of biological activity.Here we investigated the chemopreventive effects and underlying molecular mechanisms of dietary administration of hydroxylated PMFs in an azoxymethane-induced colonic tumorigenesis model.Male ICR mice at age of 6 weeks were injected with azoxymethane (AOM) twice weekly at a dose of 5 mg/kg for two weeks and continuously fed control diet or diets containing 0.01 and 0.05% hydroxylated PMFs, respectively.Mice were then sacrificed at 6 and 20 weeks, and colonic tissues were collected and examined.Hydroxylated PMFs feeding dose-dependently decreased the number of aberrant crypt foci (ACF) in colonic tissues of mice.Molecular analysis exhibited the anti-proliferative, anti-inflammatory, anti-angiogenic and pro-apoptotic activities ofhydroxylated PMFs by significantly decreasing the levels of iNOS, COX-2, cyclin D1 and VEGF through interfering with Wnt/β-catenin and EGFR/Ras/MAPK signaling pathways as well as the activation of transcription factors NF-κB and STAT3 in colonic tissue, thus resulted in suppression of colonic tumorigenesis.
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