【摘 要】
：
Up to date, small molecules that can selectively target cancer stem cells are still very rare, and basically have no common structural feature.We discovered a series of compounds that can selectively
【机 构】
：
Nankai University China
【出 处】
：
BITs 3rd Annual World Cancer Congress-2012(2012第五届世界癌症大会)
论文部分内容阅读
Up to date, small molecules that can selectively target cancer stem cells are still very rare, and basically have no common structural feature.We discovered a series of compounds that can selectively ablate AML stem/progenitor cells, and then established the first preliminary SAR against AML stem/progenitor cells.In ex-vivo experiment with NOD/SCID mice models, the survived primary AML cells after treatment with these compounds demonstrated significantly lower engraftment in mice than the equal amount of saline treated primary AML cells.Drug candidate ACT001, demonstrates excellent therapeutic effect when doses orally, and is well-tolerated in acute and chronic toxicity study.The broad therapeutic index indicates that ACT001 is a promising anti-cancer drug candidate for clinical trial.
其他文献
Steroids and H2 blockers are commonly used in supportive care for taxane-containing chemotherapy, but they also affect the primary metabolizer of docetaxel, cytochrome P450 3A4.This retrospective obse
Compelling evidence suggests that cancer cells are generally under reactive oxygen species (ROS) stress.As mitochondria respiration is the main source of ROS generation in the cells, MnSOD is of prime
Emerging evidence suggested that acute myeloid leukemia stem cells (AML LSC) are enriched in the CD34+CD38-CD123+ subpopulation.Due to low expression of coxsackie-adenovirus recptor (CAR) in both AML
Nowadays cancer is seriously threat to humans life and heath.Lung cancer is one of most malignant tumors worldwide.Genetic disorder is considered the main reason to be responsible for the happiness of
Blood protein antigens and antibodies are recognised as promising biomarkers for early detection of cancers and their progression.Blood antigens seem more effective on detecting advanced stage cancers
Breast MRI is known as the most accurate imaging modality for evaluating the response to neoadjuvant chemotherapy (NAC), which is a very important treatment option that patients with stage Ⅱ or higher
Objectives FDG-PET/CT is widely use for initial staging and recurrence of HNSCC.Its prognostic value has already been shown particularly tumoral SUVmax measured at initial staging is without real esta
Multispectral Optoacoustic Tomography (MSOT) is a powerful novel imaging modality that decomposes the spectral response of tissue chromophores in vivo, with high resolution and at depths of up to seve
New opportunities for novel therapeutic strategies against carcinomas are emerging with the accumulating evidence for the existence of cancer stem cells.These cells represent a subpopulation distingui
Gastrointestinal symptoms are common.Depending on the symptoms profile, dyspeptic symptoms ranged from 15-40%, reflux symptoms 15-25% and irritable bowel symptoms 10-20%.A proportion of patients have