【摘 要】
：
New opportunities for novel therapeutic strategies against carcinomas are emerging with the accumulating evidence for the existence of cancer stem cells.These cells represent a subpopulation distingui
【机 构】
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CNIO Spanish National Cancer Research Centre Spain
【出 处】
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BITs 3rd Annual World Cancer Congress-2012(2012第五届世界癌症大会)
论文部分内容阅读
New opportunities for novel therapeutic strategies against carcinomas are emerging with the accumulating evidence for the existence of cancer stem cells.These cells represent a subpopulation distinguishable from the bulk of the tumour by their exclusive ability to drive in vivo tumourigenesis based on their extensive self-renewal capacity and their ability to repopulated the entire tumour.Most importantly, they play a crucial role in disease relapse due to their inherent resistance to current therapies such as chemo-or radiotherapy.Therefore, the elucidation of the regulatory machinery of cancer stem cells including their interplay with the tumour microenvironment is of crucial relevance for the development of clinically more efficient therapies.Our most recent studies now provide evidence for the re-activation of a developmental pathway reminiscent of those found in embryonic stem cells.We were able to identify Nodal and Activin as two critical components determining the two-way communication between cancer stem cells and an embryonic-like microenvironment.This pathway is essential for their self-renewal capacity as well as invasiveness and therefore represents a novel therapeutic target for this deadly disease.Intriguingly, the Nodal/Activin is not only expressed in pancreatic cancer stem cells, but also in pancreatic stellate cells, which are abundantly present in the stroma surrounding pancreatic cancer cells, and serve as a supportive niche for cancer stem cells.Our preclinical studies showed that the cancer stem cell compartment can be severely altered by inhibition of this pathway resulting in chemo-sensitisation of the cancer stem cells rendering them susceptible to elimination by standard chemotherapy resulting in disease stabilization.
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