A Striatal Enriched GPCR Modulates Mutant Huntingtin Level and Toxicity via cAMP-dependent but PKA-i

来源 :The 10th Chinese Symposium on Calcium Signaling(第十届全国钙信号和细胞功 | 被引量 : 0次 | 上传用户：longxue1211

【摘要】

：

Huntingtons disease (HD) is an autosomal dominant neurodegenerative disorder caused by cytotoxicity of the mutant huntingtin (mHtt) protein.While mHtt is ubiqui

【作者】

：

Yuwei Yao Xiaotian Cui Ismael Al-Ramahi Lixiang Ma Jiapeng Hou James Palacino Juan Botas Boxun Lu

【机构】

：

StateKeyLaboratoryofGeneticEngineering,SchoolofLifeSciences,FudanUniversity,Shanghai,ChinaDepartment

【出处】

：

The 10th Chinese Symposium on Calcium Signaling(第十届全国钙信号和细胞功

【发表日期】

：

2014年7期

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

Huntingtons disease (HD) is an autosomal dominant neurodegenerative disorder caused by cytotoxicity of the mutant huntingtin (mHtt) protein.While mHtt is ubiquitously expressed, HD is characterized by selective degeneration of the corpus striatum, which is partially caused by a slower clearance rate of mHtt in the striatal neurons, suggesting existence of striatal-enriched mHtt stabilizers.

其他文献

KSHV ENCODED ORF59 PROTEIN RECRUITS PROTEIN ARGININE METHYL TRANSFERASE 5 (PRMT5) TO MODULATE CHROMA

Kaposis sarcoma associated herpesvirus (KSHV) persists in a highly ordered chromatin structure during latent infection with majority of the genome having repres

会议

DOWNREGULATION OF PARP-1 BY A VIRAL PROCESSIVITY FACTOR TO FACILITATE KSHV LYTIC REPLICATION

Poly (ADP-ribose) polymerase-1 (PARP-1) is an abundant nuclear protein that catalyzes the serial transfer of the ADP-ribose moiety of NAD+ to various target pro

会议

ORF59 COOPERATES WITH ORF40 IN DISTORTING THE AT-RICH PALINDROME REGION OF MURINE GAMMAHERPESVIRUS 6

Lytic replication is essential to virus spread and plays important roles in tumorigenesis caused by gammaherpesviruses.Murine gammaherpesvirus-68 (MHV-68) is ge

会议

GLUTAMATE SECRETION AND METABOTROPIC GLUTAMATE RECEPTOR 1 EXPRESSION DURING KAPOSIS SARCOMA-ASSOCIAT

The progression of KSHV associated KS and PEL occurs by the proliferation of cells latently infected with KSHV, which is highly dependent on autocrine and parac

会议

Functional and structural study of the large-conductance voltage-and ca2+-activated potassium (BK) c

The large-conductance voltage-and ca2+-activated potassium (BK) channel has many physiological roles including the control of firing patterns in neurons, and th

会议

P2X4 forms functional ATP-activated cation channels on lysosomal membranes regulated by luminal pH

P2X receptors are commonly known as plasma membrane cation channels involved in a wide variety of cell functions.The properties of these channels have been exte

会议

Developmental Changes of Calcium Signaling andTRPC6 Channels during Differentiation of Conditionally

The transient receptor potential canonical (TRPC)6 channel is an important ion channel located in podocytes, which plays an essential role in regulating calcium

会议

Monitoring neural circuitry with genetically encoded indicators of neural activity

Studies of neuron-astrocyte interactions over the past several decades, although controversial,have largely painted a picture where astrocytes actively respond

会议

Presynaptic receptors for botulinum neurotoxins

Botulinum neurotoxins are a family of bacterial toxins.They target presynaptic nerve terminals and function by blocking Ca2+ triggered exocytosis of synaptic ve

会议

The Role of Substance P at the Local Area of Acupoints in Acupuncture Effect

Objective:Observe the function of substance P (SP) at acupoint areas in the process of initiation of acupuncture taking effect,reveal the key and basic factors

会议

acupunctureinitiationsubstance P

A Striatal Enriched GPCR Modulates Mutant Huntingtin Level and Toxicity via cAMP-dependent but PKA-i

其他学术论文