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A dual-targeting (cellular and subcellular targeting) strategy was designed to enhance the efficacy of a porphyrin-based photodynamic therapy (PDT) system by using a folic acid (FA) modified and pH-responsive polymeric micelle (Fig.1A).For this system,a cationic porphyrin was used as a mitochondria-specific photosensitizer,and a crosslinked tri-block copolymer micelle as the carrier [1,2].