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Recently,stimuli-responsive nanocarriers have obtained more attention for the targeted and controlled delivery of therapeutics [1].Among them,nanocarriers with targeting ligands and temperature sensitivity are highly useful for cell specific drug delivery.Importantly,the amphiphilic behavior of these materials can easily help to form micelles or micelle-like aggregates with a hydrophobic core and hydrophilic surface based on the self-assembly in aqueous media.Our contribution promotes a biocompatible thermoresponsive lipopolymer hybrid system with an active targeting capacity by supramolecular decorations,which offer an additional advantage to enhance the specificity of site directed cell surface for improved endocytosis [2].