Novel reversibly crosslinked chimaeric polypeptide polymersomes for active loading and intracellular

• 作 者: JintianWu;XiaoleiGu;ChaoDeng;FenghuaMeng;JianZhang;RuCheng;ZhiyuanZhong;
• 机 构: Biomedical Polymers Laboratory,and Jiangsu Key Laboratory of Advanced Functional Polymer Design and
• 出 处: The Third Symposium on Innovative Polymers for Controlled De
• 发表日期: 2014年期

　　The disulfide-crosslinking approach has shown to elegantly resolve the extracellular stability and intracellular drug release dilemma of nanomedicines [1,2].In this study,novel reversibly crosslinked chimaeric polymersomes were developed from lipoic acid (LA) decorated poly(ethylene glycol)-poly(L-lysine)-poly(L-aspartic acid) (PEG-P(LL-LA)-PAsp) triblock copolymers for efficient loading and triggered intracellular release of doxorubicin hydrochloride (DOX·HC1).LA is a natural antioxidant produced by human body.