BMSCs paracrine repairs smoke inhalation injury: angiogenesis involving Notch signaling pathway

• 作 者: Feng Zhu Junjie Wang Yichao Jin Xiaochen Qiu Jiahui Li Zhaofan Xia
• 机 构: Burns Institute of PLA,Changhai Hospital,Second Military Medical University,Shanghai,China 200433;De
• 出 处: 中国医师协会创伤外科医师分会成立筹备大会、第八届全国创伤外科学术研讨会暨第二届阳明危重病急救医学论坛
• 发表日期: 2014年7期
• 关键词: smoke inhalation injury bone marrow-derived mesenchymal stem cells paracrine ang

　　Smoke inhalation injury is acute lung injury induced by smoke exposure characterized by vascular endothelial injury and increased permeability.Cell therapy is an attractive new therapeutic approach, though its underlying mechanism and signaling pathway remain poorly understood.We investigated the effect of systemic transplantation of preconditioned bone marrow-derived mesenchymal stem cells (BMSCs) on angiogenesis in rat model of smoke inhalation injury, and explore the underlying mechanism and possible signaling pathway.