Dearomative Indole [5+2] Cycloaddition Reaction

• 作 者: Chuang-chuangLi;
• 机 构: Department of Chemistry,South University of Science and Technology of China,Shenzhen518055,China
• 出 处: 中国化学会第29届学术年会
• 发表日期: 2014年期

　　Dearomatization of indoles has been a powerful and potentially versatile strategy to construct many unprecedented complex alkaloids from structurally simple substrates.1 The first dearomative indole [5+2] cycloaddition reaction with an oxidopyrylium ylide resulted in efficient and diastereoselective construction of some highly functionalized and synthetically challenging oxa-cyclohepta[b]indoles.The protocol notably proceeded under very mild conditions enabling high functional-group tolerance and unique endo-selectivity.2