Icariin improve the learning and memory functions in APP/PS1 transgenic mice through NO-cGMP-PDE5 si

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：niguibo

【摘要】

：

【作者】

：

Feng JIN Qi-hai Gong Fei LI Ya-sha Xu Li-na WANG Qin WU Jing-shan SHI

【机构】

：

Department of Pharmacology and the Key Laboratory of Basic Pharmacology of Guizhou Province, Zunyi M

【出处】

：

The 12th Meeting of the Asia Pacific Federation of Pharmacol

【发表日期】

：

2013年4期

【关键词】

：

icariin learning and memory functions APP/PS1 transgenic mice NOcGMP-PDE5 signal

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

Aim: To investigate the effects of icariin (ICA) on learning and memory functions in APP/PS1 transgenic mice and analyze its mechanism.Methods: The APP/PS1 transgenic mice (10 months) were randomly divided into APP/PS1 group, ICA group (30, 60 mg/kg) and sildenafil (SIL) group (2 mg/kg), the wildtype mice (10 months) were randomly divided into blank group and normal administration group (ICA 60 mg/kg).

其他文献

An antidepressant from Chinese herbs Improves the burst firing of medial prefrontal cortex induced b

Aim: Discovery of new antidepressants from traditional Chinese medicine is one of the promising field for the treatment of the major depressive disorders.Furostanol saponins (termed B3 in this study),

会议

CMSdepressionneuronal activitymPFCVTABDNF

Long term regular physical exercise improve chronic unpredictable stress induced depression and cogn

Aim: There are increasingly reports of beneficial effects of exercise on depressive disorder and cognitive impairment in humans.Cognitive impairment is one of the main symptoms in depression.However,

会议

physical exercisedepressioncognitive impairmentchronic unpredictable stress

Neuroprotective effect of 20(R)-ginsenoside Rg3 against delayed neuronal injury induced by transient

Aim: To investigate whether 20(R)-ginsenoside Rg3 (20(R)-Rg3) exhibits neuroprotective effect against delayed neuronal injury induced by transient cerebral ischemia and reperfusion in rats.Methods: Ad

会议

20(R)-ginsenoside Rg3apoptosiscalpain Ⅰcaspase-3

Neuroprotective and antitremor effect of baicalein on experimental Parkinsonism

Aim: An attempt has been made to explore the neuroprotective and antitremor effect of baicalein on neurons against experimental Parkinsonism.Methods: In in vitro experiments, we found that baicalein c

会议

BaicaleinParkinson's disease6-hydroxydopamineneuroprotective

n-Butanol extract of Chinese toon fruit ameliorated focal brain ischemic insult in rats via inhibiti

Aim: To evaluate the neuroprotective efficacy of Chinese toon on cerebral ischemic reperfusion model of rats and explored the underlying mechanisms.Methods: Rats were subjected to occlusion of the mid

会议

brain ischemiamiddle cerebral artery occlusionoxidative stresscyclooxygenase

Xanthotoxol ameliorates the ischemia/reperfusion-induced impairment of long-term potentiation induct

Aim: Cerebral ischemia can impair the induction of activity-dependent longterm potentiation (LTP) in the hippocampus.Here, we investigated the effect of xanthotoxol on the induction of activity-depend

会议

xanthotoxolLTPcerebral ischemia/reperfusionNR2ANR2B

Danggui-Shaoyao-San improves learning and memory in SAMP8

Aim: Previous studies showed that Danggui-Shaoyao-San (DSS), a traditional Chinese medicinal prescription, could alleviate cognitive dysfunction of Alzheimers disease (AD) patients.However, the mechan

会议

Danggui-Shaoyao-San (DSS)Alzheimer's disease (AD)senescence-accelerated m

Clerodendron bungei steud relieves pain hypersensitivity and its possible mechanisms in rats with ne

Aim: There are studies demonstrated that neuroimmune system was involved in the generation of neuropathic pain, cytokines are the key molecule in connection of nerve and immune.It is well known that p

会议

Clerodendron bungei steudneuropathic paincytokine

α7nAchR mediate the protective effect of GSS on brain ischemia/reperfusion injury

Aim: To explore the protective effects of Genistein Sulfonate Sodium (GSS) on brain ischemia/reperfusion (I/R) injury and its mechanism about cholinergic anti-inflammatory pathway.Methods: The rats we

会议

Genistein Sulfonic Sodiumcerebral ischemia/reperfusionα7nAChR

Neuroprotective effects of plant extracts against the neurotoxicity induced by rotenone, a mitochond

Aim: Rotenone, an inhibitor of mitochondnal complex Ⅰ, has been widely regarded as a neurotoxin because it induces a Parkinsons disease-like syndrome.The plant extracts have been used as traditional m

会议

plant extractsneuroprotective effectsrotenonePC12 cellsmitochondrial dysfunc

Icariin improve the learning and memory functions in APP/PS1 transgenic mice through NO-cGMP-PDE5 si

其他学术论文