Study of miR-200b involvement in RMP7 selectively opening blood-tumor barrier

• 作 者: TengMA;Yi-XueXUE;
• 机 构: Department of Neurobiology,College of Basic Medicine,China Medical University,Shenyang,Liaoning 1100
• 出 处: 第一届辽宁省神经科学学会学术研讨会
• 发表日期: 2014年期

　　Objective We have previously shown that activation of RhoA\ROCK by bradykinin(BK)and is associated with cytoskeleton rearrangement,tight junction(TJ)protein disassembly and down-regulation of ZO-1,occludin,and claudin-5,and an increase in blood–tumor barrier(BTB)permeability in rat brain microvascular endothelial cells(RBMECs).We investigated whether miR-200b play a key role in the above-mentioned processes by RMP7(a BK analogs)in human brain microvascular endothelial cells HBMECs.