【摘 要】
：
1.Ron overexpression induces highly metastatic breast cancer.The Ron receptor tyrosine kinase has recently been shown to be overexpressed and activated in a
【机 构】
：
DepartmentofCancerandCellBiologyUniversityofCincinnatiCollegeofMedicineUSA
【出 处】
：
2011第四届世界癌症大会暨乳腺癌峰会
论文部分内容阅读
1.Ron overexpression induces highly metastatic breast cancer.The Ron receptor tyrosine kinase has recently been shown to be overexpressed and activated in a cohort of human cancers, with the most compelling data found in breast cancer.Ron is overexpressed in approximately 50% of human breast cancers, and has been shown to be an independent predictor of both metastases and poor prognosis in women with this disease.While Ron overexpression appears to be an important factor in human breast cancer and metastasis, a significant gap exists in our knowledge about the signaling pathways that Ron activates in breast tumors, and about the importance of these pathways with respect to overall tumor growth and metastatic dissemination.
其他文献
药物效应存在种族和个体差异，是导致严重的药物不良反应，惊人的经济损失，在研新药的夭折，已上市药物被迫撤出市场的直接和重要原因.我国每年有5000万住院患者，因药物不良反应
背景：癫痫是神经系统的常见疾病,特别是儿童多发,严重影响患者的生活质量,是一特殊群体.癫痫治疗的主要手段是使用抗癫痫药.然而,抗癫痫药,尤其是丙戊酸钠,通常在患者中间
Voltage-Gated Potassium Channels (Kv) are involved in proliferation and transformation in mammary epithelial cells.In previous studies, several groups have
Mortality from breast cancer is almost entirely the result of invasion and metastasis of neoplastic cells; therefore, understanding gene products involved i
The discovery of new cancer biomarkers and attempts to unravel the molecular circuitry involved in tumor development, progression and metastasis continues t
The use of high field MRR H1 spectroscopy can measure tCho Invivo.Results of numerous ex vivo and in vivo studies have shown that neoplastic breast tissue c
Triple negative breast cancer (TNBC) that lacks the expression of estrogen receptor alpha (ERα), progesterone receptor (PR) and over-expression of human ep