Axonal plasticity protein GAP43 regulates gephyrin aggregation in developing GABAergic synapses

• 作 者: Yi-Hsuan Lee
• 机 构: Department and Institute of Physiology,Brain Research Center,National Yang-Ming University,Taipei
• 出 处: 2016年国际生理学学术大会
• 发表日期: 2016年6期
• 关键词: GAP43 gephyrin GABAA receptor neonatal hypoxia

　　Proper development of inhibitory GABAergic synapses is critical for establishing an excitatory/inhibitory balance in the neural network.The impairment of postsynaptic GABAA receptor(GABAAR)activity is a major cause of neuronal hyperactivity,affecting cognitive development and psychosocial behaviors.Postsynaptic surface insertion and clustering of GABAARs determine the efficacy of GABAergic synapses.