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Objective: To detect the inhibitory effects of CAL-101, a selective inhibitor of PI3K(&), on the Burkitt lymphoma cell line Raji and the diffuse large B-cell lymphoma (DLBCL) cell line SUDHL-10 and to detect the relative mechanism of CAL-101.Methods: Raji and SUDHL-10 cells were treated with various concentrations of CAL-101.An MTT assay was performed to determine the inhibitory effect of CAL-101 on lymphoma cells, and cell apoptosis was measured using Annexin Ⅴ/PI and 4-6-diamidino-2-phenylindole (DAPI) staining.Transwell migration assays were performed to detect the migration of lymphoma cells as derived by the stromal cell line HK.Western blot analysis was used to detect the phosphorylation of the ERK pathway.MTT and CalcuSyn software analyses were performed to determine whether the combination of CAL-101 with bortezomib induced synergistic cytotoxicity.