【摘 要】
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Objective: To evaluate the expression of CXCR4 and the migration rate of bone marrow CD34+ cells in different myelodysplastic syndrome (MDS) risk groups and to perform the correlation analysis between
【机 构】
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Department of Hematology,Tianjin Medical University Cancer Institute and Hospital,Key Laboratory of
【出 处】
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22nd Asia Pacific Cancer Conference(第22届亚太抗癌大会)
论文部分内容阅读
Objective: To evaluate the expression of CXCR4 and the migration rate of bone marrow CD34+ cells in different myelodysplastic syndrome (MDS) risk groups and to perform the correlation analysis between the expression of CXCR4 and the migration rate of CD34+ cells.Methods: A total of 40 patients diagnosed with MDS were divided into low-grade and high-grade groups according to the International Prostate Symptom Score (IPSS) system.Twenty low-grade MDS patients had IPSS ＜1.5 and 20 high-grade MDS patients had IPSS ≥1.5.Bone marrow (BM) samples of the patients and 10 healthy controls were collected.The CD34+cells were separated and purified; the expression of CXCR4 was detected using flow cytometry; and the migration rate of the CD34+ cells based on the chemotactic effect of SDF-1α, as well as on the effect of bone marrow stromal cells, was measured.A correlation analysis between the expression of CXCR4 and the migration rate of CD34+ cells was performed.
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