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目的:观察中药和胃宝颗粒剂在体外培养条件下对幽门螺杆菌(Hp)生长的影响,以及和胃宝颗粒剂存在时Hp对几种常用抗生素敏感性的影响。方法:将Hp接种于含不同浓度和胃宝颗粒剂的布氏肉汤中培养,测定和胃宝对三种菌株的抑制直径的改变。E检测法检测和胃宝对甲硝唑等抗生素MIC的影响。结果:(1)和胃宝颗粒剂可抑制Hp的生长,这种抑制作用与甲硝唑大致相当,明显优于克拉霉素。(2)和胃宝颗粒剂存在时,分别使100%,75%及75%的Hp对甲硝唑及克拉霉素的MIC降低,提示和胃宝颗粒剂可使Hp对上述抗生素的敏感性增高。结论:和胃宝颗粒剂可抑制Hp的生长,提高Hp对甲硝唑、克拉霉素及羟氨苄青霉素的敏感性。
Objective: To observe the effects of traditional Chinese medicine and Weibao granules on the growth of Helicobacter pylori (Hp) under in vitro culture conditions, and the influence of Hp on the sensitivity of several commonly used antibiotics in the presence of Weibao granules. METHODS: Hp was inoculated into Brucella broth with different concentrations of Weibao granules, and the inhibition diameter of Heweibao was determined. E detection method was used to detect the effect of Heweibao on metronidazole and other antibiotics MIC. Results: (1) Heweibao granule could inhibit the growth of Hp. The inhibitory effect was similar to that of metronidazole, which was obviously better than that of clarithromycin. (2) In the presence of Heweibao granules, the MICs of 100%, 75%, and 75% of Hp on metronidazole and clarithromycin were decreased, suggesting that Heweibao granules can make Hp sensitive to the above antibiotics. Increased. Conclusion: Heweibao granules can inhibit the growth of Hp and increase the sensitivity of Hp to metronidazole, clarithromycin and amoxycillin.