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  5. SAHA Treatment Reveals the link between Histone Lysine Acetylation and Proteome in Non-small Cell Lu

SAHA Treatment Reveals the link between Histone Lysine Acetylation and Proteome in Non-small Cell Lu

来源 :第八届中国蛋白质组学大会 | 被引量 : 0次 | 上传用户：ILOVELUBIN
【摘 要】
：
Suberoylanilide hydroxamic acid (SAHA) is a well-known pan HDAC inhibitor and its clinical application (Vorinostat) has beendemonstrated to treat non-small cell lung cancer (NSCLS).Nevertheless,the im
【作 者】
：
Quan Wu Weiqing Xu Xin Li Zhongyi Cheng 
【机 构】
：
Central Laboratory,Affiliated Provincial Hospital,Anhui Medical University,Hefei,P.R.China,230001
【出 处】
：
第八届中国蛋白质组学大会
【发表日期】
：
2013年11期
【关键词】
：
SAHA NSCLC A549 cells Histone lysine acetylation Proteome 
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Suberoylanilide hydroxamic acid (SAHA) is a well-known pan HDAC inhibitor and its clinical application (Vorinostat) has beendemonstrated to treat non-small cell lung cancer (NSCLS).Nevertheless,the impact of SAHA treatment on histone lysine acetylationand proteome in NSCLS cells still need further elucidate.In NSCLS A549 cells,by using stable isotope labeling for cell culture (SILAC)based quantitative proteomics,biochemistry assay and bioinformatic analysis,here we for the first time comprehensively identifiedand quantified histone lysine acetylation in A549 cells towards SAHA treatment.
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