调控雌激素生物合成的天然产物的发现及其作用机制研究

来源 :中国化学会第十届全国天然有机化学学术会议 | 被引量 : 0次 | 上传用户：wuln2909

【摘要】

：

芳香化酶(aromatase;CYP19A1)是体内介导雌激素合成的关键酶,它以雄激素为底物催化合成雌激素.芳香化酶在多个组织中表达,虽然其蛋白质编码区一致,但在不同组织中使用的启动子并不相同,因此,芳香化酶在不同组织中的表达调控机制具有差异1.虽然目前临床上已经开发出芳香化酶抑制剂(anastrozole、letrozole和exemstane),用于治疗雌激素依赖的乳腺癌,其疗效优于目前常用的

【作者】

：

郭加加袁韵熊亮石建功袁小红张国林王飞

【机构】

：

天然药物及临床转化重点实验室,中国科学院成都生物研究所,成都,610041 天然药物及临床转化重点

【出处】

：

中国化学会第十届全国天然有机化学学术会议

【发表日期】

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2014年11期

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调控雌激素生物合成的天然产物的发现及其作用机制研究

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